Healthcare professional consulting with a patient

Information for participants

Everything you need to know about taking part in the FREEDOM trial.

Am I eligible?

You may be eligible to participate if you meet the following criteria:

Have attended UHCW miscarriage clinic under Prof. Quenby
Diagnosed with luteal phase insufficiency
Age 18-45
Not currently pregnant or breastfeeding
Clear understanding of written/spoken English

Your participation journey

The trial consists of three study rounds. You will be randomly assigned to start with either Cyclogest® or Callavid®, then cross-over to the other product.

If you become pregnant during the trial, your participation
will end and you will return to your usual care.

Round 1
7 days
First treatmentCyclogest® or Callavid® (2hr)
Round 2
7 days
Switch productOther treatment
Round 3
7 days
Final treatmentCallavid® only (3hr)
View detailed flowchart
FREEDOM trial flowchart showing screening, randomisation, and three rounds of treatment with Cyclogest<sup>®</sup> and Callavid<sup>®</sup>

At a glance

Key information about time commitment and reimbursement

4 months
Study duration
Up to
6 visits
Hospital appointments
3 blood samples
Per visit

Refreshments provided

Tea, coffee, snacks & lunch during hospital visits

Childcare costs

Reasonable childcare expenses reimbursed

Travel & parking

Travel and parking costs reimbursed

Reimbursment for hospital visits

Refer to the PIS for more information

Participant Information Sheet (PIS)

Full details about the study, including what to expect, potential risks and benefits, and your rights as a participant.

Download PDF

Your rights as a participant

Voluntary

Participation is completely voluntary

Withdraw anytime

You can leave the study at any time

Confidential

Your data is protected and anonymous

No impact on care

Declining won't affect your NHS treatment